| Total | 635 | 192 | (30%) | 155 | (24%) | 288 | (45%) |
| Casa | 316 | 129 | (41%) | 79 | (25%) | 108 | (34%) |
| Fuera | 319 | 63 | (20%) | 76 | (24%) | 180 | (56%) |
D | 2021-12-10 | Mariupol |  | 0-3 |  | Dnipro-1 | J18 | ||
E | 2021-12-05 | Desna |  | 3-3 | | Mariupol | J17 | ||
D | 2021-11-26 | Mariupol | | 0-1 |  | FC Lviv | J16 | ||
D | 2021-11-21 | Vorskla |  | 5-1 | | Mariupol | J15 | ||
V | 2021-11-06 | Mynai |  | 0-2 | | Mariupol | J14 | ||
D | 2021-10-30 | Mariupol | | 2-3 |  | Dynamo Kyiv | J13 | ||
D | 2021-10-23 | FC Veres |  | 2-0 | | Mariupol | J12 | ||
D | 2021-10-16 | Mariupol | | 1-2 |  | Metalist 1925 Kharkov | J11 | ||
D | 2021-10-01 | Mariupol | | 0-2 |  | Rukh Vynnyky | J10 | ||
D | 2021-09-25 | PFC Oleksandriya |  | 2-1 | | Mariupol | J9 | ||
D | 2021-09-18 | Mariupol | | 0-5 |  | Shakhtar Donetsk | J8 | ||
V | 2021-09-12 | Kolos Kovalivka |  | 1-3 | | Mariupol | J7 | ||
D | 2021-08-28 | Inhulets Petrove |  | 3-0 | | Mariupol | J6 | ||
D | 2021-08-22 | Mariupol | | 3-4 |  | Zorya | J5 | ||
D | 2021-08-16 | Mariupol | | 2-3 |  | Chornomorets | J4 | ||
D | 2021-08-07 | Dnipro-1 | | 2-1 | | Mariupol | J3 | ||
D | 2021-08-01 | Mariupol | | 1-2 | | Desna | J2 | ||
E | 2021-07-23 | FC Lviv | | 1-1 | | Mariupol | J1 | ||
V | 2021-05-09 | Mariupol | | 4-1 | | Desna | J26 | ||
E | 2021-05-05 | Dynamo Kyiv | | 0-0 | | Mariupol | J25 |
